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A Role for Accessory Genes rI.-1 and rI.1 in the Regulation of Lysis Inhibition by Bacteriophage T4

Piotr Golec, Aleksandra Wiczk, Anna Majchrzyk, Joanna M Łoś, Grzegorz Węgrzyn, Marcin Łoś

Virus Genes. 2010 Dec;41(3):459-68.

PMID: 20945083

Abstract:

Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP415713609 RI-1 RI-1 415713-60-9 Price
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