Home
Resources
Publications
Analgesic Effects of Toad Cake and Toad-cake-containing Herbal Drugs: Analgesic Effects of Toad Cake

Analgesic Effects of Toad Cake and Toad-cake-containing Herbal Drugs: Analgesic Effects of Toad Cake

Eiji Inoue, Yasuharu Shimizu, Ryo Masui, Tomomi Usui, Keiichi Sudoh

J Pharmacopuncture. 2014 Mar;17(1):74-9.

PMID: 25780693

Abstract:

Objectives:
This study was conducted to clarify the analgesic effect of toad cake and toad-cake-containing herbal drugs.
Methods:
We counted the writhing response of mice after the intraperitoneal administration of acetic acid as a nociceptive pain model and the withdrawal response after the plantar surface stimulation of the hind paw induced by partial sciatic nerve ligation of the mice as a neuropathic pain model to investigate the analgesic effect of toad cake and toad-cake-containing herbal drugs. A co-treatment study with serotonin biosynthesis inhibitory drug 4-chloro- DL-phenylalanine methyl ester hydrochloride (PCPA), the catecholamine biosynthesis inhibitory drug α-methyl- DL-tyrosine methyl ester hydrochloride (AMPT) or the opioid receptor antagonist naloxone hydrochloride was also conducted.
Results:
Analgesic effects in a mouse model of nociceptive pain and neuropathic pain were shown by oral administration of toad cake and toad-cake-containing herbal drugs. The effects of toad cake and toad-cake-containing herbal drugs disappeared upon co-treatment with PCPA, but not with AMPT or naloxone in the nociceptive pain model; the analgesic effect of toad-cake-containing herbal drugs also disappeared upon co-treatment with PCPA in the neuropathic pain model.
Conclusion:
Toad cake and toad-cake-containing herbal drugs have potential for the treatments of nociceptive pain and of neuropathic pain, such as post-herpetic neuralgia, trigeminal neuralgia, diabetic neuralgia, and postoperative or posttraumatic pain, by activation of the central serotonin nervous system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14173401	4-Chloro-DL-phenylalanine methyl ester hydrochloride		14173-40-1	Price
AP7361311	α-Methyl-DL-tyrosine methyl ester hydrochloride		7361-31-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: