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Enduring Amnesia Induced by ICV Scopolamine Is Reversed by Sesame Oil in Male Rats

Enduring Amnesia Induced by ICV Scopolamine Is Reversed by Sesame Oil in Male Rats

Shabnam-Sadat Seyedi Tabari, Shirin Babri, Fariba Mirzaie, Fereshteh Farajdokht, Gisou Mohaddes

Acta Cir Bras. 2016 Aug;31(8):520-6.

PMID: 27579879

Abstract:

Purpose:
To evaluated the long-term effect of scopolamine and sesame oil on spatial memory.
Methods:
Memory impairment induced by Intracerebroventricular (ICV) injection of scopolamine hydrochloride (10 μg/ rat). Animals were gavaged for 4 weeks with saline, sesame oil (0.5, 1, or 2 mL/kg/day), or 3 weeks with memantine (30 mg/kg/day) in advance to induction of amnesia. Morris water maze (MWM) test was conducted 6 days after microinjection of scopolamine. Then, blood and brain samples were collected and evaluated for the malondialdehyde (MDA) levels, superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, and total antioxidant status (TAS) and ferric reducing ability of plasma (FRAP).
Results:
Scopolamine significantly decreased traveled distance and time spent in target quadrant in probe test. Pretreatment of rats with sesame oil (0.5 mg/kg) mitigated scopolamine-induced behavioral alterations. Measurement of MDA, SOD, and GPX in brain tissue, and FRAP and TAS in blood showed little changes in animals which had received scopolamine or sesame oil.
Conclusions:
Intracerebroventricular injection of scopolamine has a residual effect on memory after six days. Sesame oil has an improving effect on spatial memory; however this effect is possibly mediated by mechanisms other than antioxidant effect of sesame oil.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP55163	(−)-Scopolamine hydrochloride		55-16-3	Price

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