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Expression of Raf Kinase Inhibitor Protein Is Downregulated in Response to Newcastle Disease Virus Infection to Promote Viral Replication

Expression of Raf Kinase Inhibitor Protein Is Downregulated in Response to Newcastle Disease Virus Infection to Promote Viral Replication

Renfu Yin, Xinxin Liu, Yuhai Bi, Guangyao Xie, Pingze Zhang, Xin Meng, Lili Ai, Rongyi Xu, Yuzhang Sun, Tobias Stoeger, Zhuang Ding

J Gen Virol. 2015 Sep;96(9):2579-2586.

PMID: 26297355

Abstract:

Newcastle disease virus (NDV) causes a severe and economically significant disease affecting almost the entire poultry industry worldwide. However, factors that affect NDV replication in host cells are poorly understood. Raf kinase inhibitory protein (RKIP) is a physiological inhibitor of c-RAF kinase and NF-κB signalling, known for their functions in the control of immune response as well as tumour invasion and metastasis. In the present study, we investigated the consequences of overexpression of host RKIP during viral infection. We demonstrate that NDV infection represses RKIP expression thereby promoting virus replication. Experimental upregulation of RKIP in turn acts as a potential antiviral defence mechanism in host cells that restricts NDV replication by repressing the activation of Raf/MEK/ERK and IκBα/NF-κB signalling pathways. Our results not only extend the concept of linking NDV-host interactions, but also reveal RKIP as a new class of protein-kinase-inhibitor protein that affects NDV replication with therapeutic potential.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP331444407	Raf Kinase Inhibitor VI - CAS 331444-40-7		331444-40-7	Price

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