Home
Resources
Publications
Liposome Formulations of O-Carborane for the Boron Neutron Capture Therapy of Cancer

Liposome Formulations of O-Carborane for the Boron Neutron Capture Therapy of Cancer

Temidayo O B Olusanya, Gianpiero Calabrese, Dimitrios G Fatouros, John Tsibouklis, James R Smith

Biophys Chem. 2019 Apr;247:25-33.

PMID: 30797076

Abstract:

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80-100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16872096	o-Carborane		16872-09-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: