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Mouse and Human Cell Activation by N-dodecanoyl-DL-homoserine Lactone, a Chromobacterium Violaceum Autoinducer

Kazunori Gomi, Toshiaki Kikuchi, Yutaka Tokue, Shigeru Fujimura, Akiko Uehara, Haruhiko Takada, Akira Watanabe, Toshihiro Nukiwa

Infect Immun. 2006 Dec;74(12):7029-31.

PMID: 16982829

Abstract:

Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP76924953 N-(β-Ketocaproyl)-DL-homoserine lactone N-(β-Ketocaproyl)-DL-homoserine lactone 76924-95-3 Price
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