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Pachypodol, a Flavonol From the Leaves of Calycopteris Floribunda, Inhibits the Growth of CaCo 2 Colon Cancer Cell Line in Vitro

Pachypodol, a Flavonol From the Leaves of Calycopteris Floribunda, Inhibits the Growth of CaCo 2 Colon Cancer Cell Line in Vitro

Husne-Ara Ali, A K Azad Chowdhury, Abul K M Rahman, Tomasz Borkowski, Lutfun Nahar, Satyajit D Sarker

Phytother Res. 2008 Dec;22(12):1684-7.

PMID: 18570232

Abstract:

Calycopteris floribunda Lam., commonly known as 'goichia lata or goache lata', is a large climbing woody shrub from Bangladesh, and well distributed in a number of other south-east Asian countries. Traditionally, C. floribunda has been used in colic, as an antihelminthic, astringent and carminative, and for the treatment of diarrhoea, dysentery, jaundice and malaria in many countries including Bangladesh. Pachypodol (5,4'-dihydroxy-3,7,3'-trimethoxyflavone) has been isolated from the leaves of C. floribunda by repeated column chromatography on silica gel, and the structure confirmed by spectroscopic means. While the general toxicity of pachypodol was determined by the brine shrimp lethality assay, the cytotoxic potential of this flavonoid has been evaluated by the Promega's CellTiter 96 Non-Radioactive Cell Proliferation Assay using the CaCo-2 colon cancer cell line (IC(50) = 185.6 microM). A summary of the biological activities of pachypodol reported to date is also presented.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33708724	Pachypodol		33708-72-4	Price

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