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Pharmacoeconomic Review Report: Tiotropium Bromide Monohydrate and Olodaterol Hydrochloride (Inspiolto Respimat) for Oral Inhalation [Internet]

Pharmacoeconomic Review Report: Tiotropium Bromide Monohydrate and Olodaterol Hydrochloride (Inspiolto Respimat) for Oral Inhalation [Internet]

PMID: 30883067

Abstract:

Inspiolto Respimat (tiotropium bromide monohydrate/olodaterol hydrochloride [TIO/OLO]) is a fixeddose combination of a long-acting muscarinic antagonist (LAMA), tiotropium, and a long-acting beta2 agonist (LABA), olodaterol, indicated for the long-term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. TIO/OLO is available as a multi-use cartridge to be used with the Respimat device, which provides 2.5 mcg of TIO and 2.5 mcg of OLO per actuation. The recommended dose of TIO/OLO is two actuations once daily ($2.10 daily).
The manufacturer is requesting a listing as per the Health Canada-approved indication and in a similar manner to other fixed-dose combinations indacaterol plus glycopyrronium (IND/GLY) and umeclidinium plus vilanterol (UMEC/VI): for the long-term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema, if the following clinical criteria are met: moderate to severe COPD as defined by spirometryinadequate response to a long-acting bronchodilator (LABA) or long-acting anticholinergic.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP411207313	Tiotropium bromide monohydrate		411207-31-3	Price

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