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Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase

Dongyin Chen, Fengguo Xu, Pu Zhang, Jie Deng, Hongbin Sun, Xiaoan Wen, Jun Liu

Arch Pharm (Weinheim). 2017 Dec;350(12).

PMID: 29027714

Abstract:

A practical synthesis of α-amyrin (1), β-amyrin (2), and lupeol (3) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid (4), oleanolic acid (5), and betulin (6), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP638959 α-Amyrin α-Amyrin 638-95-9 Price
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