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Protective Effect of Nordihydroguaiaretic Acid (NDGA) Against Norgestrel Induced Genotoxic Damage

Protective Effect of Nordihydroguaiaretic Acid (NDGA) Against Norgestrel Induced Genotoxic Damage

Yasir Hasan Siddique, Tanveer Beg, Mohammad Afzal

Toxicol In Vitro. 2006 Mar;20(2):227-33.

PMID: 16061348

Abstract:

Nordihydroguaiaretic acid (NDGA) is a phenolic lignan and possesses antioxidant and number of properties potentially useful to man. The effect of NDGA was studied against norgestrel induced genotoxic damage, using sister chromatid exchanges (SCEs), chromosomal aberrations (CAs), mitotic index (MI) and replication index (RI) as parameters. Amounts of 5, 10 and 20 microM of norgestrel was tested for its genotoxic effect in the absence as well as presence of S9 mix, and was found to be genotoxic at 10 and 20 microM in the presence of S9 mix. Again, 10 microM of norgestrel was treated with 0.5 and 1 microM of NDGA, separately, in the presence of S9 mix. Similar treatment was given with 20 microM of norgestrel. Treatments given with NDGA result in the reduction of SCE, CA and increase of MI as well as RI, suggesting its protective action on human lymphocytes in vitro against the norgestrel induced genotoxic damage.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP500389-A	NDGA - CAS 500-38-9		500-38-9	Price

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