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RIFM Fragrance Ingredient Safety Assessment, Benzyl Propionate, CAS Registry Number 122-63-4

RIFM Fragrance Ingredient Safety Assessment, Benzyl Propionate, CAS Registry Number 122-63-4

A M Api, D Belsito, S Bhatia, M Bruze, P Calow, M L Dagli, W Dekant, A D Fryer, L Kromidas, S La Cava, J F Lalko, A Lapczynski, D C Liebler, V T Politano, G Ritacco, D Salvito, T W Schultz, J Shen, I G Sipes, etc.

Food Chem Toxicol. 2016 Nov;97S:S38-S48.

PMID: 26702987

Abstract:

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP122634	Benzyl propionate		122-63-4	Price

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