Home
Resources
Publications
Sulfur-Doped Graphene-Based Immunological Biosensing Platform for Multianalysis of Cancer Biomarkers

Sulfur-Doped Graphene-Based Immunological Biosensing Platform for Multianalysis of Cancer Biomarkers

Xiang Ren, Hongmin Ma, Tong Zhang, Yong Zhang, Tao Yan, Bin Du, Qin Wei

ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37637-37644.

PMID: 28994581

Abstract:

The accurate tumor marker detection at an early stage can prevent people from getting cancer to a great extent. Herein, a novel tri-antibody dual-channel biosensing strategy is applied in multianalysis of carcino-embryonic antigen (CEA) and nuclear matrix protein 22 (NMP22). In this immunosensor fabrication process, graphene oxide/polyaniline nanostructures are used as matrix and mesoporous NKF-5-3 is used as labels. Two kinds of antigens can be obtained from the signals of neutral red and toluidine blue, respectively, which are modified on the labels. In this tri-antibody dual-channel biosensing platform, sulfur-doped graphene sheet is synthesized by click chemistry as the framework structure. Majority of the incubations are conducted in individual steps, which ensure the surface incubation more tightly. The detection limit of NMP22 and CEA are 25 and 30 fg/mL, respectively. The low detection limit and excellent stability can ascribe to the tri-antibody dual-channel strategy, which makes the sensor platform from surface to the space. The clinical urine sample analysis achieves a good performance. The urine-based test can avoid the secondary injury on hemophilia or ischemic patients, displaying a potential application in clinical diagnosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS76149	Sulfur-doped graphene			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: