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Synthesis and Antimicrobial Activity of Novel Benzoxazoles

Synthesis and Antimicrobial Activity of Novel Benzoxazoles

Mustafa Arisoy, Ozlem Temiz-Arpaci, Fatma Kaynak-Onurdag, Selda Ozgen

Z Naturforsch C J Biosci. Sep-Oct 2012;67(9-10):466-72.

PMID: 23198404

Abstract:

A series of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]acetamido]-benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. Their structures were elucidated by spectral techniques. These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drug-resistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. The minimum inhibitory concentration (MIC) of each compound was determined by a two-fold serial dilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 32-256 microg/ml. Although standard drugs were more active against the pathogenes employed in this study, the activities of the new benzoxazoles and reference drugs against drug-resistant isolates of the microorganisms were largely similar.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP1397893	Amphotericin B trihydrate		1397-89-3 (anhydrous)	Price

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