Home
Resources
Publications
The Objective and Timing of Drug Disposition Studies, Appendix II. Plasma Concentrations of Oxyphenbutazone in Dogs Given Oxyphenbutazone or the Calcium or Sodium Salts of Its Phosphate Ester

The Objective and Timing of Drug Disposition Studies, Appendix II. Plasma Concentrations of Oxyphenbutazone in Dogs Given Oxyphenbutazone or the Calcium or Sodium Salts of Its Phosphate Ester

R H Hook, C J Eastwood Jr, G J Wright

Drug Metab Rev. 1975;4(2):249-65.

PMID: 1222682

Abstract:

Plasma levels of oxyphenbutazone were measured in beagle dogs following oral administration of oxyphenbutazone and salts of oxyphenbutazone phosphate. Dosage with sodium and calcium salts of oxyphenbutazone phosphate produced higher oxyphenbutazone plasma levels than dosage with oxyphenbutazone itself. Oxyphenbutazone phosphate was not detected in plasma following oral dosing with salts of oxyphenbutazone phosphate but was found in plasma following intramuscular administration of oxyphenbutazone phosphate sodium salt. A metabolite, oxyphenbutazone glucuronide, was found in plasma of dogs following administration of either oxyphenbutazone or salts of oxyphenbutazone phosphate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP129204	Oxyphenbutazone		129-20-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: