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Tissue Deconjugation of Urolithin A Glucuronide to Free Urolithin A in Systemic Inflammation

M A Ávila-Gálvez, J A Giménez-Bastida, A González-Sarrías, J C Espín

Food Funct. 2019 Jun 19;10(6):3135-3141.

PMID: 31041969

Abstract:

Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1143700 Urolithin A Urolithin A 1143-70-0 Price
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