CAS 59468-90-5 1′-Hydroxymidazolam - Analytical Products / Alfa Chemistry

CAT	AP59468905-B
CAS	59468-90-5
Structure
MDL Number	MFCD00871458
Molecular Weight	341.77
InChI Key	QHSMEGADRFZVNE-UHFFFAOYSA-N

Color	white to off-white
Size	5MG, 10MG
Storage Conditions	2-8°C

1

Characterization of 1'-hydroxymidazolam Glucuronidation in Human Liver Microsomes

Bing Zhu, David Bush, George A Doss, Stella Vincent, Ronald B Franklin, Shiyao Xu

Drug Metab Dispos. 2008 Feb;36(2):331-8.

PMID: 17998299

1

Development and Validation of a Sensitive Assay for Analysis of Midazolam, Free and Conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in Pediatric Plasma: Application to Pediatric Pharmacokinetic Study

Ganesh S Moorthy, Harini Jogiraju, Christina Vedar, Athena F Zuppa

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 1;1067:1-9.

PMID: 28978489

1

Differential Depression of Neuronal Network Activity by Midazolam and Its Main Metabolite 1-hydroxymidazolam in Cultured Neocortical Slices

Monika Balk, Harald Hentschke, Uwe Rudolph, Bernd Antkowiak, Berthold Drexler

Sci Rep. 2017 Jun 14;7(1):3503.

PMID: 28615640

1

Metabolism of 1'- And 4-hydroxymidazolam by Glucuronide Conjugation Is Largely Mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7

Kyung-Ah Seo, Soo Kyung Bae, Young-Kil Choi, Chang Soo Choi, Kwang-Hyeon Liu, Jae-Gook Shin

Drug Metab Dispos. 2010 Nov;38(11):2007-13.

PMID: 20713656

1

Single Plasma Concentrations of 1'-hydroxymidazolam or the Ratio of 1'-hydroxymidazolam:midazolam Do Not Predict Midazolam Clearance in Healthy Subjects

Janyce F Rogers, Anne N Nafziger, Angela D M Kashuba, Daniel S Streetman, Mario L Rocci Jr, Edna F Choo, Grant R Wilkinson, Joseph S Bertino Jr

J Clin Pharmacol. 2002 Oct;42(10):1079-82.

PMID: 12362920

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