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10058-F4

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For Research Use Only | Not For Clinical Use
CATAP403811552-A
CAS403811-55-2
Structure
MDL NumberMFCD00758517
Molecular Weight249.35
InChI KeySVXDHPADAXBMFB-JXMROGBWSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: >10 mg/mL; H2O: <2 mg/mL
Assay≥98% (HPLC)
Coloryellow
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

10058-F4, a c-Myc Inhibitor, Markedly Increases Valproic Acid-Induced Cell Death in Jurkat and CCRF-CEM T-lymphoblastic Leukemia Cells

Qitian Mu, Qiuling Ma, Shasha Lu, Ting Zhang, Mengxia Yu, Xin Huang, Jian Chen, Jie Jin

Oncol Lett. 2014 Sep;8(3):1355-1359.

PMID: 25120723

1

Efficacy, Pharmacokinetics, Tisssue Distribution, and Metabolism of the Myc-Max Disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in Mice

Jianxia Guo, Robert A Parise, Erin Joseph, Merrill J Egorin, John S Lazo, Edward V Prochownik, Julie L Eiseman

Cancer Chemother Pharmacol. 2009 Mar;63(4):615-25.

PMID: 18509642

1

Inhibition of c-Myc by 10058-F4 Induces Growth Arrest and Chemosensitivity in Pancreatic Ductal Adenocarcinoma

Meng Zhang, Hai-Yan Fan, Sheng-Chao Li

Biomed Pharmacother. 2015 Jul;73:123-8.

PMID: 26211592

1

Small Molecule Inhibitor of c-Myc 10058-F4 Inhibits Proliferation and Induces Apoptosis in Acute Leukemia Cells, Irrespective of PTEN Status

Davood Bashash, Mohamad Sayyadi, Ava Safaroghli-Azar, Negar Sheikh-Zeineddini, Niknam Riyahi, Majid Momeny

Int J Biochem Cell Biol. 2019 Mar;108:7-16.

PMID: 30639430

1

Suppression of c-Myc Using 10058-F4 Exerts caspase-3-dependent Apoptosis and Intensifies the Antileukemic Effect of Vincristine in pre-B Acute Lymphoblastic Leukemia Cells

Negar Sheikh-Zeineddini, Davood Bashash, Ava Safaroghli-Azar, Niknam Riyahi, Rima Manafi Shabestari, Ehsan Janzamin, Majid Safa

J Cell Biochem. 2019 Aug;120(8):14004-14016.

PMID: 30957273

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