CAS 53949-53-4 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid

CAT	AP53949534-B
CAS	53949-53-4
Structure
MDL Number	MFCD08275586
Molecular Weight	222.28
InChI Key	RMOQYHYFRKTDRI-UHFFFAOYSA-N
REAXYS Number	22307543

Description	pharmaceutical impurity standard
Assay	≥98.0% (HPLC)
Impurity Content	≤0.5% water
Size	50MG

1

An Innovative Approach to the Analysis of 3-[4-(2-methylpropyl)phenyl]propanoic Acid as an Impurity of Ibuprofen on a Carbon-Coated Zirconia Stationary Phase

P Kalafut, R Kucera, J Klimes, J Sochor

J Pharm Biomed Anal. 2009 Jul 12;49(5):1150-6.

PMID: 19307077

1

Chemo-Enzymatic Synthesis, Structural and Stereochemical Characterization, and Intrinsic Degradation Kinetics of Diastereomers of 1-β- O-Acyl Glucuronides Derived from Racemic 2-{4-[(2-Methylprop-2-en-1-yl)amino]phenyl}propanoic Acid

Akiko Baba, Koki Yamada, Takashi Satoh, Kazuhiro Watanabe, Tadao Yoshioka

ACS Omega. 2018 May 4;3(5):4932-4940.

PMID: 31458709

1

Design and Optimization of 2,3-dihydrobenzo[b][1,4]dioxine Propanoic Acids as Novel GPR40 Agonists With Improved Pharmacokinetic and Safety Profiles

Bin Guo, Shimeng Guo, Jing Huang, Jingya Li, Jia Li, Qian Chen, Xianli Zhou, Xin Xie, Yushe Yang

Bioorg Med Chem. 2018 Dec 1;26(22):5780-5791.

PMID: 30392954

1

Evaluation of the cyclopentane-1,2-dione as a Potential Bio-Isostere of the Carboxylic Acid Functional Group

Carlo Ballatore, Bryant Gay, Longchuan Huang, Katie Herbst Robinson, Michael J James, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Amos B Smith 3rd

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4171-5.

PMID: 25127105

1

The Effect of Breast Cancer Resistance Protein and P-glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice

Lin Zhou, Kari Schmidt, Frederick R Nelson, Veronica Zelesky, Matthew D Troutman, Bo Feng

Drug Metab Dispos. 2009 May;37(5):946-55.

PMID: 19225039

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