CAS 374750-30-8 2′-C-Methylguanosine - Analytical Products / Alfa Chemistry

CAT	AP374750308
CAS	374750-30-8
Structure
Molecular Weight	297.27

Description	≥98% (HPLC)
Solubility	H2O: 5 mg/mL, clear (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

Antiviral Candidates Against the Hepatitis E Virus (HEV) and Their Combinations Inhibit HEV Growth in in Vitro

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Antiviral Res. 2019 Oct;170:104570.

PMID: 31362004

1

Phosphoramidate ProTides of 2'-C-methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties

Christopher McGuigan, Arnaud Gilles, Karolina Madela, Mohamed Aljarah, Sabrina Holl, Sarah Jones, John Vernachio, Jeff Hutchins, Brenda Ames, K Dawn Bryant, Elena Gorovits, Babita Ganguly, Damound Hunley, etc.

J Med Chem. 2010 Jul 8;53(13):4949-57.

PMID: 20527890

1

Structure-activity Relationship of Heterobase-Modified 2'-C-methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Anne B Eldrup, Marija Prhavc, Jennifer Brooks, Balkrishen Bhat, Thazha P Prakash, Quanlai Song, Sanjib Bera, Neelima Bhat, Prasad Dande, P Dan Cook, C Frank Bennett, Steven S Carroll, Richard G Ball, Michele Bosserman, etc.

J Med Chem. 2004 Oct 7;47(21):5284-97.

PMID: 15456273

1

Synthesis and Evaluation Against Hepatitis C Virus of 7-deaza Analogues of 2'-C-methyl-6-O-methyl Guanosine Nucleoside and L-Alanine Ester Phosphoramidates

Claire Bourdin, Christopher McGuigan, Andrea Brancale, Stanley Chamberlain, John Vernachio, Jeff Hutchins, Elena Gorovits, Alexander Kolykhalov, Jerry Muhammad, Joseph Patti, Geoffrey Henson, Blair Bleiman, etc.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2260-4.

PMID: 23453067

1

The Phosphoramidate ProTide Approach Greatly Enhances the Activity of beta-2'-C-methylguanosine Against Hepatitis C Virus

Christopher McGuigan, Plinio Perrone, Karolina Madela, Johan Neyts

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4316-20.

PMID: 19523820

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