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2-D08

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For Research Use Only | Not For Clinical Use
CATAP144707186
CAS144707-18-6
Molecular Weight270.24
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

2-D08 as a SUMOylation Inhibitor Induced ROS Accumulation Mediates Apoptosis of Acute Myeloid Leukemia Cells Possibly Through the deSUMOylation of NOX2

Pan Zhou, Xing Chen, Mengke Li, Jiaqi Tan, Yicheng Zhang, Weiping Yuan, Jianfeng Zhou, Gaoxiang Wang

Biochem Biophys Res Commun. 2019 Jun 11;513(4):1063-1069.

PMID: 31010676

1

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity

Sukanya Das, Tara L Pukala, Scott D Smid

Front Chem. 2018 May 25;6:181.

PMID: 29888220

1

K-Ras Lys-42 Is Crucial for Its Signaling, Cell Migration, and Invasion

Byeong Hyeok Choi, Mark R Philips, Yuan Chen, Lou Lu, Wei Dai

J Biol Chem. 2018 Nov 9;293(45):17574-17581.

PMID: 30228186

1

Structure-activity Relationships for Flavone Interactions With Amyloid β Reveal a Novel Anti-Aggregatory and Neuroprotective Effect of 2',3',4'-trihydroxyflavone (2-D08)

Dylan T Marsh, Sukanya Das, Jessica Ridell, Scott D Smid

Bioorg Med Chem. 2017 Jul 15;25(14):3827-3834.

PMID: 28559058

1

Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation

Yeong Sang Kim, Samantha G L Keyser, John S Schneekloth Jr

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.

PMID: 24468414

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