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2-PMPA

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For Research Use Only | Not For Clinical Use
CATAP173039106
CAS173039-10-6
Structure
MDL NumberMFCD00940167
Molecular Weight226.12
InChI KeyISEYJGQFXSTPMQ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityH2O: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Effects of NAAG Peptidase Inhibitor 2-PMPA in Model Chronic Pain - Relation to Brain Concentration

Jens Nagel, Irina Belozertseva, Sergio Greco, Vladimir Kashkin, Andrey Malyshkin, Aigars Jirgensons, Elena Shekunova, Bernd Eilbacher, Anton Bespalov, Wojciech Danysz

Neuropharmacology. 2006 Dec;51(7-8):1163-71.

PMID: 16926034

1

Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) From Its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

Ranjeet P Dash, Tomáš Tichý, Vijayabhaskar Veeravalli, Jenny Lam, Jesse Alt, Ying Wu, Lukáš Tenora, Pavel Majer, Barbara S Slusher, Rana Rais

Mol Pharm. 2019 Oct 7;16(10):4292-4301.

PMID: 31503493

1

Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-PMPA Reduces Rewarding Effects of the Synthetic Cathinone MDPV in Rats: A Role for N-acetylaspartylglutamate (NAAG)

Callum Hicks, Ryan A Gregg, Sunil U Nayak, Lee Anne Cannella, Giana J Schena, Christopher S Tallarida, Allen B Reitz, Garry R Smith, Scott M Rawls

Psychopharmacology (Berl). 2017 Jun;234(11):1671-1681.

PMID: 28251297

1

Inhibition of NAALADase by 2-PMPA Attenuates Cocaine-Induced Relapse in Rats: A NAAG-mGluR2/3-mediated Mechanism

Zheng-Xiong Xi, Xia Li, Xiao-Qing Peng, Jie Li, Lauren Chun, Eliot L Gardner, Ajit G Thomas, Barbara S Slusher, Charles R Ashby Jr

J Neurochem. 2010 Jan;112(2):564-76.

PMID: 19895667

1

Neuroprotection Produced by the NAALADase Inhibitor 2-PMPA in Rat Cerebellar Neurons

F C Tortella, Y Lin, H Ved, B S Slusher, J R Dave

Eur J Pharmacol. 2000 Aug 18;402(1-2):31-7.

PMID: 10940354

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