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4μ8C

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For Research Use Only | Not For Clinical Use
CATAP14003964
CAS14003-96-4
Structure
Molecular Weight204.18
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

4μ8C Inhibits Insulin Secretion Independent of IRE1α RNase Activity

Hitomi Sato, Yoko Shiba, Yuichi Tsuchiya, Michiko Saito, Kenji Kohno

Cell Struct Funct. 2017 May 3;42(1):61-70.

PMID: 28321016

1

Bax inhibitor-1 Protects From Nonalcoholic Steatohepatitis by Limiting Inositol-Requiring Enzyme 1 Alpha Signaling in Mice

Cynthia Lebeaupin, Déborah Vallée, Déborah Rousseau, Stéphanie Patouraux, Stéphanie Bonnafous, Gilbert Adam, Frederic Luciano, Carmelo Luci, Rodolphe Anty, Antonio Iannelli, Sandrine Marchetti, Guido Kroemer, etc.

Hepatology. 2018 Aug;68(2):515-532.

PMID: 29457838

1

Regulation of IRE1α by the Small Molecule Inhibitor 4μ8c in Hepatoma Cells

Claire Stewart, Andrea Estrada, Paul Kim, Dong Wang, Yuren Wei, Chris Gentile, Michael Pagliassotti

Endoplasmic Reticulum Stress Dis. 2017 Apr;4(1):1-10.

PMID: 29098149

1

Suppression of IgE-mediated Mast Cell Activation and Mouse Anaphylaxis via Inhibition of Syk Activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C

Seung Taek Nam, Young Hwan Park, Hyun Woo Kim, Hyuk Soon Kim, Dajeong Lee, Min Bum Lee, Young Mi Kim, Wahn Soo Choi

Toxicol Appl Pharmacol. 2017 Oct 1;332:25-31.

PMID: 28736076

1

Treatment of Established TH2 Cells With 4μ8c, an Inhibitor of IRE1α, Blocks IL-5 but Not IL-4 Secretion

Cody Poe, Cheyanne Youngblood, Karissa Hodge, Kyeorda Kemp

BMC Immunol. 2019 Jan 10;20(1):3.

PMID: 30630412

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