CAS 3133-16-2 4-Octyl itaconate - Analytical Products / Alfa Chemistry

CAT	AP3133162
CAS	3133-16-2
Molecular Weight	242.31

Description	≥98% (HPLC)
Solubility	DMSO: 2 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients

Chun Tang, Xiaohua Wang, Yingying Xie, Xiaoyan Cai, Na Yu, Yudan Hu, Zhihua Zheng

Cell Physiol Biochem. 2018;51(2):979-990.

PMID: 30466076

1

4-Octyl Itaconate Inhibits Aerobic Glycolysis by Targeting GAPDH to Exert Anti-Inflammatory Effects

Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong

Nat Commun. 2019 Nov 8;10(1):5091.

PMID: 31704924

1

Activation of Keap1-Nrf2 Signaling by 4-octyl Itaconate Protects Human Umbilical Vein Endothelial Cells From High Glucose

Chun Tang, Shengyu Tan, Yiqing Zhang, Lini Dong, Yan Xu

Biochem Biophys Res Commun. 2019 Jan 15;508(3):921-927.

PMID: 30545629

1

Itaconate Is an Anti-Inflammatory Metabolite That Activates Nrf2 via Alkylation of KEAP1

Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C Runtsch, Martin S King, etc.

Nature. 2018 Apr 5;556(7699):113-117.

PMID: 29590092

1

Nrf2 Negatively Regulates STING Indicating a Link Between Antiviral Sensing and Metabolic Reprogramming

David Olagnier, Aske M Brandtoft, Camilla Gunderstofte, Nikolaj L Villadsen, Christian Krapp, Anne L Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, etc.

Nat Commun. 2018 Aug 29;9(1):3506.

PMID: 30158636

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