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5HPP-33

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For Research Use Only | Not For Clinical Use
CATAP105624860
CAS105624-86-0
Structure
MDL NumberMFCD03085294
Molecular Weight323.39
InChI KeyLAKWINYVWJPHQW-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: >20 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

A Thalidomide Analogue With in Vitro Antiproliferative, Antimitotic, and Microtubule-Stabilizing Activities

Pui-Kai Li, Bulbul Pandit, Dan L Sackett, Zhigen Hu, Jennifer Zink, Jiandong Zhi, Dena Freeman, Robert W Robey, Karl Werbovetz, Andrew Lewis, Chenglong Li

Mol Cancer Ther. 2006 Feb;5(2):450-6.

PMID: 16505120

1

New Tubulin Polymerization Inhibitor Derived From Thalidomide: Implications for Anti-Myeloma Therapy

Masahiro Kizaki, Yuichi Hashimoto

Curr Med Chem. 2008;15(8):754-65.

PMID: 18393844

1

Novel Tubulin-Polymerization Inhibitor Derived From Thalidomide Directly Induces Apoptosis in Human Multiple Myeloma Cells: Possible Anti-Myeloma Mechanism of Thalidomide

Toyotaka Iguchi, Tomomi Yachide-Noguchi, Yuichi Hashimoto, Sawako Nakazato, Morihiko Sagawa, Yasuo Ikeda, Masahiro Kizaki

Int J Mol Med. 2008 Feb;21(2):163-8.

PMID: 18204782

1

Structure-activity Relationship Studies of Thalidomide Analogs With a Taxol-Like Mode of Action

Bulbul Pandit, Zhigen Hu, Somsundaram N Chettiar, Jennifer Zink, Zili Xiao, Jonathan P Etter, Deepak Bhasin, Pui-Kai Li

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6902-4.

PMID: 24169233

1

Thalidomide (5HPP-33) Suppresses Microtubule Dynamics and Depolymerizes the Microtubule Network by Binding at the Vinblastine Binding Site on Tubulin

Aijaz Rashid, Annapurna Kuppa, Ambarish Kunwar, Dulal Panda

Biochemistry. 2015 Mar 31;54(12):2149-59.

PMID: 25747795

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