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5Z-7-Oxozeaenol

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For Research Use Only | Not For Clinical Use
CATAP253863193
CAS253863-19-3
MDL NumberMFCD12912700
Molecular Weight362.37
InChI KeyNEQZWEXWOFPKOT-BYRRXHGESA-N
Description≥98% (HPLC)
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formpowder
Size1MG
Storage Conditions2-8°C
1

(5Z)-7-Oxozeaenol: A Novel and Potent Resorcylic Acid Lactone Kinase Inhibitor With a Cis-Enone Michael Acceptor

George A Ellestad

Chirality. 2019 Feb;31(2):110-117.

PMID: 30565749

1

5Z-7-Oxozeaenol Covalently Binds to MAP2K7 at Cys218 in an Unprecedented Manner

Yuri Sogabe, Takashi Matsumoto, Takuma Hashimoto, Yasuyuki Kirii, Masaaki Sawa, Takayoshi Kinoshita

Bioorg Med Chem Lett. 2015 Feb 1;25(3):593-6.

PMID: 25529738

1

Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation

Lingli Lu, Xiuping Zhang, Huichun Tong, Wenlong Zhang, Pingyi Xu, Shaogang Qu

Front Pharmacol. 2017 Nov 3;8:789.

PMID: 29163172

1

Effects of (5Z)-7-oxozeaenol on MDA-MB-231 Breast Cancer Cells

Ulyana Muñoz Acuña, Jennifer Wittwer, Sloan Ayers, Cedric J Pearce, Nicholas H Oberlies, Esperanza J Carcache DE Blanco

Anticancer Res. 2012 Jul;32(7):2415-21.

PMID: 22753698

1

TAK1 Inhibitor 5Z-7-oxozeaenol Sensitizes Cervical Cancer to Doxorubicin-Induced Apoptosis

Shan Guan, Jiaxiong Lu, Yanling Zhao, Sarah E Woodfield, Huiyuan Zhang, Xin Xu, Yang Yu, Jing Zhao, Shayahati Bieerkehazhi, Haoqian Liang, Jianhua Yang, Fuchun Zhang, Surong Sun

Oncotarget. 2017 May 16;8(20):33666-33675.

PMID: 28430599

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