(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride

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For Research Use Only | Not For Clinical Use

CAT	AP69056388
CAS	69056-38-8
Structure
MDL Number	MFCD00891665
Molecular Weight	314.17
InChI Key	RKSUYBCOVNCALL-NTVURLEBSA-N

Solubility	water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
Size	5MG, 25MG, 100MG
Storage Conditions	−20°C

Efficacy of Sapropterin Dihydrochloride (Tetrahydrobiopterin, 6R-BH4) for Reduction of Phenylalanine Concentration in Patients With Phenylketonuria: A Phase III Randomised Placebo-Controlled Study

Harvey L Levy, Andrzej Milanowski, Anupam Chakrapani, Maureen Cleary, Philip Lee, Friedrich K Trefz, Chester B Whitley, François Feillet, Annette S Feigenbaum, Judith D Bebchuk, Heidi Christ-Schmidt, Alex Dorenbaum, etc.

Lancet. 2007 Aug 11;370(9586):504-10.

PMID: 17693179

International Best Practice for the Evaluation of Responsiveness to Sapropterin Dihydrochloride in Patients With Phenylketonuria

Ania C Muntau, Darius J Adams, Amaya Bélanger-Quintana, Tatiana V Bushueva, Roberto Cerone, Yin-Hsiu Chien, Ana Chiesa, Turgay Coşkun, Javier de Las Heras, François Feillet, Rachel Katz, Florian Lagler, etc.

Mol Genet Metab. 2019 May;127(1):1-11.

PMID: 31103398

Neurohypophysial Vasopressin and Oxytocin as Influenced by (6R)-5,6,7,8-tetrahydro-alpha-biopterin in Euhydrated and Dehydrated Rats

J Ciosek, J W Guzek, M Orłowska-Majdak

Biol Chem Hoppe Seyler. 1992 Oct;373(10):1079-83.

PMID: 1418678

Sapropterin

PMID: 32401468

Sapropterin Dihydrochloride, 6-R-L-erythro-5,6,7,8-tetrahydrobiopterin, in the Treatment of Phenylketonuria

Kimberlee Michals-Matalon

Expert Opin Investig Drugs. 2008 Feb;17(2):245-51.

PMID: 18230057

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