CAS 227609-66-7 A-278637 - Analytical Products / Alfa Chemistry

CAT	AP227609667
CAS	227609-66-7
Molecular Weight	412.27

Description	≥98%
Solubility	DMSO: 5 mg/mL, clear (warmed)
Assay	≥98%
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Novel ATP-sensitive Potassium Channel Opener: Hemodynamic Comparison to ZD-6169, WAY-133537, and Nifedipine in the Anesthetized Canine

Ryan M Fryer, Lee C Preusser, Samuel V Calzadilla, Yanhui Hu, Hongyu Xu, Kennan C Marsh, Bryan F Cox, C Thomas Lin, Murali Gopalakrishnan, Glenn A Reinhart

J Cardiovasc Pharmacol. 2004 Aug;44(2):137-47.

PMID: 15243293

1

(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): A Novel ATP-sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization

Murali Gopalakrishnan, Steven A Buckner, Kristi L Whiteaker, Char-Chang Shieh, Eduardo J Molinari, Ivan Milicic, Anthony V Daza, Rachel Davis-Taber, Victoria E Scott, Donna Sellers, Russ Chess-Williams, etc.

J Pharmacol Exp Ther. 2002 Oct;303(1):379-86.

PMID: 12235274

1

(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): A Novel ATP-sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization

Michael E Brune, Thomas A Fey, Jorge D Brioni, James P Sullivan, Michael Williams, William A Carroll, Michael J Coghlan, Murali Gopalakrishnan

J Pharmacol Exp Ther. 2002 Oct;303(1):387-94.

PMID: 12235275

1

K-ATP Opener-Mediated Attenuation of Spontaneous Bladder Contractions in Ligature-Intact, Partial Bladder Outlet Obstructed Rats

James J Lynch 3rd, Michael E Brune, Nathan L Lubbers, Michael J Coghlan, Bryan F Cox, James S Polakowski, Linda L King, James P Sullivan, Jorge D Brioni

Life Sci. 2003 Mar 14;72(17):1931-41.

PMID: 12597992

1

Synthesis and Structure-Activity Relationships of a Novel Series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) Channel Openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Potent K(ATP) Opener That Selectively Inhibits Spontaneous Bladder Contractions

William A Carroll, Robert J Altenbach, Hao Bai, Jorge D Brioni, Michael E Brune, Steven A Buckner, Christopher Cassidy, Yiyuan Chen, Michael J Coghlan, Anthony V Daza, Irene Drizin, Thomas A Fey, Michael Fitzgerald, etc.

J Med Chem. 2004 Jun 3;47(12):3163-79.

PMID: 15163196

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