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A-740003

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For Research Use Only | Not For Clinical Use
CATAP861393284
CAS861393-28-4
Structure
MDL NumberMFCD09970333
Molecular Weight474.55
InChI KeyPUHSRMSFDASMAE-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Prisca Honore, Diana Donnelly-Roberts, Marian T Namovic, Gin Hsieh, Chang Z Zhu, Joe P Mikusa, Gricelda Hernandez, Chengmin Zhong, Donna M Gauvin, Prasant Chandran, Richard Harris, Arturo Perez Medrano, etc.

J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85.

PMID: 16982702

1

IL-1β Production Is Dependent on the Activation of Purinergic Receptors and NLRP3 Pathway in Human Macrophages

Thomas Gicquel, Sacha Robert, Pascal Loyer, Tatiana Victoni, Aude Bodin, Catherine Ribault, Florence Gleonnec, Isabelle Couillin, Elisabeth Boichot, Vincent Lagente

FASEB J. 2015 Oct;29(10):4162-73.

PMID: 26116704

1

P2X 7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway

Jie Yin, Yu Wang, Hesheng Hu, Xiaolu Li, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Na Yang, Yugen Shi, Suhua Yan

J Cell Mol Med. 2017 Nov;21(11):2695-2710.

PMID: 28470940

1

Role of P2X 7 R in the development and progression of pulmonary hypertension

Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan, Xiaolu Li

Respir Res. 2017 Jun 24;18(1):127.

PMID: 28646872

1

Synthesis and Initial Preclinical Evaluation of the P2X7 Receptor Antagonist [¹¹C]A-740003 as a Novel Tracer of Neuroinflammation

Bieneke Janssen, Danielle J Vugts, Uta Funke, Arnold Spaans, Robert C Schuit, Esther Kooijman, Marissa Rongen, Lars R Perk, Adriaan A Lammertsma, Albert D Windhorst

J Labelled Comp Radiopharm. 2014 Jun 30;57(8):509-16.

PMID: 24995673

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