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A-971432

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For Research Use Only | Not For Clinical Use
CATAP1240308455
CAS1240308-45-5
MDL NumberMFCD30182357
Molecular Weight366.24
Description≥95% (HPLC)
SolubilityDMSO: 3 mg/mL, clear (warmed)
Assay≥95% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders

Adrian D Hobson, Christopher M Harris, Elizabeth L van der Kam, Sean C Turner, Ayome Abibi, Ana L Aguirre, Peter Bousquet, Tegest Kebede, Donald B Konopacki, Gary Gintant, Youngjae Kim, Kelly Larson, John W Maull, etc.

J Med Chem. 2015 Dec 10;58(23):9154-70.

PMID: 26509640

1

Stimulation of S1PR5 With A-971432, a Selective Agonist, Preserves Blood-Brain Barrier Integrity and Exerts Therapeutic Effect in an Animal Model of Huntington's Disease

Alba Di Pardo, Salvatore Castaldo, Enrico Amico, Giuseppe Pepe, Federico Marracino, Luca Capocci, Alfredo Giovannelli, Michele Madonna, Jeroen van Bergeijk, Fabio Buttari, Elizabeth van der Kam, Vittorio Maglione

Hum Mol Genet. 2018 Jul 15;27(14):2490-2501.

PMID: 29688337

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