AC-265347 - Analytical Products / Alfa Chemistry

CAT	IAR4242151
MDL Number	MFCD20527324
Molecular Weight	283.39
InChI Key	IGSZVEPQZANNAB-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥19 mg/mL
Assay	≥98% (HPLC)
Color	white to tan
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Activation of Calcium-Sensing Receptor by Allosteric Agonists Cinacalcet and AC-265347 Abolishes the 1,25(OH)

Kannikar Wongdee, Mayuree Rodrat, Chutiya Keadsai, Walailak Jantarajit, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, Narattaphol Charoenphandhu

Arch Biochem Biophys. 2018 Nov 1;657:15-22.

PMID: 30217510

1

Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine

Maria J Barahona, Renee M Maina, Taras Lysyy, Michele Finotti, Giorgio Caturegli, Vanessa Baratta, Francesco D'Amico, David Mulligan, John P Geibel

Front Physiol. 2019 May 3;10:439.

PMID: 31130866

1

Biased Allosteric Modulation at the CaS Receptor Engendered by Structurally Diverse Calcimimetics

A E Cook, S N Mistry, K J Gregory, S G B Furness, P M Sexton, P J Scammells, A D Conigrave, A Christopoulos, K Leach

Br J Pharmacol. 2015 Jan;172(1):185-200.

PMID: 25220431

1

Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor

Jian-Nong Ma, Michelle Owens, Magnus Gustafsson, Jacob Jensen, Ali Tabatabaei, Kara Schmelzer, Roger Olsson, Ethan S Burstein

J Pharmacol Exp Ther. 2011 Apr;337(1):275-84.

PMID: 21239511

1

Divergent Effects of Strontium and Calcium-Sensing Receptor Positive Allosteric Modulators (Calcimimetics) on Human Osteoclast Activity

Natalie A Diepenhorst, Katie Leach, Andrew N Keller, Patricia Rueda, Anna E Cook, Tracie L Pierce, Cameron Nowell, Philippe Pastoureau, Massimo Sabatini, Roger J Summers, William N Charman, Patrick M Sexton, etc.

Br J Pharmacol. 2018 Nov;175(21):4095-4108.

PMID: 29714810

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