CAS 447407-36-5 AC 42 - Analytical Products / Alfa Chemistry

CAT	AP447407365
CAS	447407-36-5
Molecular Weight	337.93

Description	≥98% (HPLC)
Solubility	DMSO: 5 mg/mL, clear (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

Fluorescent Derivatives of AC-42 to Probe Bitopic orthosteric/allosteric Binding Mechanisms on Muscarinic M1 Receptors

Sandrine B Daval, Céline Valant, Dominique Bonnet, Esther Kellenberger, Marcel Hibert, Jean-Luc Galzi, Brigitte Ilien

J Med Chem. 2012 Mar 8;55(5):2125-43.

PMID: 22329602

1

Probing the Molecular Mechanism of Interaction Between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M(1) Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist

Christopher J Langmead, Victoria A H Fry, Ian T Forbes, Clive L Branch, Arthur Christopoulos, Martyn D Wood, Hugh J Herdon

Mol Pharmacol. 2006 Jan;69(1):236-46.

PMID: 16207821

1

Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation

Tracy A Spalding, Jian-Nong Ma, Thomas R Ott, Mikael Friberg, Abhishek Bajpai, Stefania Risso Bradley, Robert E Davis, Mark R Brann, Ethan S Burstein

Mol Pharmacol. 2006 Dec;70(6):1974-83.

PMID: 16959945

1

The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct From the Acetylcholine Orthosteric Site

Marlene A Jacobson, Constantine Kreatsoulas, Danette M Pascarella, Julie A O'Brien, Cyrille Sur

Mol Pharmacol. 2010 Oct;78(4):648-57.

PMID: 20660086

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