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AC-7954

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For Research Use Only | Not For Clinical Use
CATAP477313090
CAS477313-09-0
Structure
MDL NumberMFCD07784497
Molecular Weight366.28
InChI KeyAJPGLOWFIBOGMH-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityH2O: ~28 mg/mL
Assay≥98% (HPLC)
Colorwhite
Formsolid
Size5MG
1

Discovery of the First Nonpeptide Agonist of the GPR14/urotensin-II Receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Glenn E Croston, Roger Olsson, Erika A Currier, Ethan S Burstein, David Weiner, Norman Nash, Daniel Severance, Stig G Allenmark, Linda Thunberg, Jian-Nong Ma, Nina Mohell, Brian O'Dowd, Mark R Brann, Uli Hacksell

J Med Chem. 2002 Nov 7;45(23):4950-3.

PMID: 12408704

1

Isochromanone-based urotensin-II Receptor Agonists

Fredrik Lehmann, Erika A Currier, Roger Olsson, Uli Hacksell, Kristina Luthman

Bioorg Med Chem. 2005 Apr 15;13(8):3057-68.

PMID: 15781415

1

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Fredrik Lehmann, Anna Pettersen, Erika A Currier, Vladimir Sherbukhin, Roger Olsson, Uli Hacksell, Kristina Luthman

J Med Chem. 2006 Apr 6;49(7):2232-40.

PMID: 16570919

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