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AC1903

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For Research Use Only | Not For Clinical Use
CATAP831234130
CAS831234-13-0
MDL NumberMFCD06609959
Molecular Weight303.36
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Small-Molecule Inhibitor of TRPC5 Ion Channels Suppresses Progressive Kidney Disease in Animal Models

Yiming Zhou, Philip Castonguay, Eriene-Heidi Sidhom, Abbe R Clark, Moran Dvela-Levitt, Sookyung Kim, Jonas Sieber, Nicolas Wieder, Ji Yong Jung, Svetlana Andreeva, Jana Reichardt, Frank Dubois, Sigrid C Hoffmann, etc.

Science. 2017 Dec 8;358(6368):1332-1336.

PMID: 29217578

1

Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases

Juan Lorenzo Pablo, Anna Greka

Trends Pharmacol Sci. 2019 Dec;40(12):911-918.

PMID: 31704171

1

Design, Synthesis and Characterization of Novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as Selective TRPC5 Inhibitors Leading to the Identification of the Selective Compound, AC1903

Swagat H Sharma, Juan Lorenzo Pablo, Monica Suarez Montesinos, Anna Greka, Corey R Hopkins

Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159.

PMID: 30538066

1

Treasure Troves of Pharmacological Tools to Study Transient Receptor Potential Canonical 1/4/5 Channels

Hussein N Rubaiy

Br J Pharmacol. 2019 Apr;176(7):832-846.

PMID: 30656647

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