CAS 8048-52-0 Acriflavine - Analytical Products / Alfa Chemistry

CAT	AP8048520
CAS	8048-52-0
Structure
MDL Number	MFCD00064307
Molecular Weight	259.73
InChI Key	PEJLNXHANOHNSU-UHFFFAOYSA-N

Description	BioReagent, suitable for fluorescence, ≥95.0% (AT)
Solubility	H2O: 0.33 g/mL (lit.)(lit.)
Assay	≥95.0% (AT)
Size	10G, 50G

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Case Study

Acriflavine Used for the Preparation of ZrO₂-Acriflavine Nanocomposite Thin Films for Optoelectronic Applications

Abd El-Aal, Mohamed, et al. Journal of Molecular Structure 1250 (2022): 131827.

Acriflavine (ACF), a planar aromatic dye with notable photophysical properties, has gained attention as a functional component in nanocomposite thin films. In this study, a novel [ZrO₂+ACF]C nanocomposite thin film was synthesized and characterized for potential optoelectronic and solar cell applications. The experimental synthesis followed a systematic route:
1. Synthesis of ZrO₂ Nanoparticles - 15.43 g of zirconium (IV) nitrate was dissolved in 100 mL of double-distilled water (1.0 M). A 1.5 M oxalic acid solution was prepared separately by dissolving 18.91 g oxalic acid dihydrate in 50 mL water. The oxalic acid solution was slowly added to zirconium nitrate under stirring at 50 °C for 2 h, followed by aging for 10 h at 25 °C and additional stirring for 30 min at 80 °C.
2. Preparation of Acriflavine Solution - 0.5 g of ACF was dissolved in 50 mL of a water/ethanol (1:1) mixture, stirred at 50 °C for 1 h to form a homogeneous solution.
3. Nanocomposite Formation - The prepared ZrO₂ nanoparticles were doped with ACF according to optimized weight ratios. The mixture was cast into Petri dishes, oven-dried at 55 °C for 15 h, and further dehydrated in a desiccator.
4. Thin Film Fabrication - The dried nanocomposite was spin-coated to produce uniform thin films.
Characterization by FTIR, UV-Vis, SEM, and DFT simulations confirmed structural integrity, with an average crystallite size of 59.76 nm and a reduced optical band gap (2.117 eV). These findings indicate that Acriflavine, when integrated into ZrO₂ matrices, enhances optoelectronic performance, making [ZrO₂+ACF]C thin films promising candidates for solar energy and photonic device applications.

Acriflavine Used for the Synthesis of Ionic Covalent Organic Frameworks for Environmental Remediation

Zhou, Yun-Jie, et al. Chemical Engineering Journal 512 (2025): 162634.

Acriflavine (AF), a low-cost aromatic dye with strong cationic functionality, has recently been identified as a promising monomer for the synthesis of ionic covalent organic frameworks (iCOFs). By combining AF with different aldehyde monomers, three novel AF-based iCOFs (AF-Tb, AF-HTb, and AF-Tp) were successfully prepared through solvothermal methods. The experimental process was outlined as follows:
1. Synthesis of AF-Tb - AF (77.9 mg, 0.3 mmol) and Tb (32.4 mg, 0.2 mmol) were dissolved in ethanol/1,4-dioxane (1:1), sonicated for 5 min, treated with CF₃COOH, and sealed in an autoclave at 120 °C for 24 h. The solid was collected, Soxhlet-washed, and vacuum-dried to yield AF-Tb.
2. Synthesis of AF-HTb - AF and HTb were dissolved in o-DCB/n-BuOH (3:1), treated with CF₃COOH, and subjected to identical heating and purification steps to yield AF-HTb.
3. Synthesis of AF-Tp - AF and Tp were dissolved in o-DCB/n-BuOH (1:1) without catalyst, followed by heating at 120 °C for 24 h and purification to yield AF-Tp.
4. Nanosheet Preparation - AF-based iCOFs were ultrasonically treated in solvents, producing nanosheets with fully exposed active sites.
Among the three, AF-Tp exhibited the strongest environmental performance, completely reducing toxic Cr(VI) to Cr(III) within 15 minutes via adsorption-assisted photocatalysis. These findings highlight acriflavine as a versatile building block for iCOFs, opening new avenues in environmental remediation and wastewater treatment.

Acriflavine Used for the Preparation of Acr/UIO-66 Fluorescent Sensor for Hypochlorite Detection in Water

Qin, Shili, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 327 (2025): 125333.

Acriflavine (Acr), a cationic dye with excellent optical properties, has recently been utilized to develop advanced functional materials for environmental monitoring. In this study, Acr was immobilized onto UIO-66, a zirconium-based metal-organic framework (MOF), through a post-synthetic modification strategy to yield Acr/UIO-66, a ratiometric fluorescent sensor designed for hypochlorite (ClO⁻) detection in aqueous systems.
The experimental procedure was carried out as follows:
1. UIO-66 Synthesis - UIO-66 was first obtained by a solvothermal method, following standard protocols.
2. Post-Synthetic Modification - Acr was sonicated in EDC aqueous solution, followed by NHS activation.
3. Composite Formation - The activated Acr solution was added to a suspension of UIO-66 and stirred at 60 °C for 6 h.
4. Product Recovery - The mixture was centrifuged, washed with ethanol to remove unbound dye, and dried under vacuum to obtain Acr/UIO-66 as a yellow powder.
5. Optimization - Four composites were prepared with different Acr:UIO-66 molar ratios (0.5:1, 1:1, 4:1, 6:1), with the optimized material showing both strong photo-response and high crystallinity.
Acr/UIO-66 exhibited remarkable sensing capabilities toward ClO⁻, featuring a fast response time (60 s), wide pH tolerance (4.0-7.0), low detection limit (0.74 µM), and excellent recovery (94.46-118.00%). These results confirm acriflavine's potential as a versatile modifier in MOF-based fluorescent platforms, providing a reliable tool for real-time water quality monitoring.