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Adaphostin

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For Research Use Only | Not For Clinical Use
CATAP241127582
CAS241127-58-2
Structure
MDL NumberMFCD06411386
Molecular Weight393.48
InChI KeyYJZSUCFGHXQWDM-ONHXBKDTSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Adaphostin Cytoxicity in Glioblastoma Cells Is ROS-dependent and Is Accompanied by Upregulation of Heme oxygenase-1

Jason Long, Tejas Manchandia, Kechen Ban, Shan Gao, Claudia Miller, Joya Chandra

Cancer Chemother Pharmacol. 2007 Mar;59(4):527-35.

PMID: 16924499

1

Adaphostin Promotes Caffeine-Evoked Autocrine Fas-mediated Death Pathway Activation in Bcr/Abl-positive Leukaemia Cells

Wen-Hsin Liu, Long-Sen Chang

Biochem J. 2011 Nov 1;439(3):453-67.

PMID: 21745187

1

Adaphostin Toxicity in a Sensitive Non-Small Cell Lung Cancer Model Is Mediated Through Nrf2 Signaling and Heme Oxygenase 1

Nicole D Fer, Robert H Shoemaker, Anne Monks

J Exp Clin Cancer Res. 2010 Jul 9;29(1):91.

PMID: 20618971

1

Combinatorial Effects of Histone Deacetylase Inhibitors (HDACi), Vorinostat and Entinostat, and Adaphostin Are Characterized by Distinct Redox Alterations

Nilsa Rivera-Del Valle, Tiewei Cheng, Mary E Irwin, Hayley Donnella, Melissa M Singh, Joya Chandra

Cancer Chemother Pharmacol. 2018 Mar;81(3):483-495.

PMID: 29313067

1

Dasmahapatra G, Rahmani M, Dent P, Grant S. The Tyrphostin Adaphostin Interacts Synergistically With Proteasome Inhibitors to Induce Apoptosis in Human Leukemia Cells Through a Reactive Oxygen Species (ROS)-dependent Mechanism.

Blood. 2019 Jul 4;134(1):95.

PMID: 31126918

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