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ADX-47273

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For Research Use Only | Not For Clinical Use
CATAP851881602
CAS851881-60-2
MDL NumberMFCD17167026
Molecular Weight369.36
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

ADX-47273, a mGlu5 Receptor Positive Allosteric Modulator, Attenuates Deficits in Cognitive Flexibility Induced by Withdrawal From 'Binge-Like' Ethanol Exposure in Rats

Marta Marszalek-Grabska, Ewa Gibula-Bruzda, Anna Bodzon-Kulakowska, Piotr Suder, Kinga Gawel, Sylwia Talarek, Joanna Listos, Ewa Kedzierska, Wojciech Danysz, Jolanta H Kotlinska

Behav Brain Res. 2018 Feb 15;338:9-16.

PMID: 29030082

1

Differential Effect of the mGlu5 Receptor Positive Allosteric Modulator ADX-47273 on Early and Late Hippocampal LTP

Katja S Kroker, Georg Rast, Holger Rosenbrock

Neuropharmacology. 2011 Sep;61(4):707-14.

PMID: 21640734

1

Discovery of Molecular Switches Within the ADX-47273 mGlu5 PAM Scaffold That Modulate Modes of Pharmacology to Afford Potent mGlu5 NAMs, PAMs and Partial Antagonists

Jeffrey P Lamb, Darren W Engers, Colleen M Niswender, Alice L Rodriguez, Daryl F Venable, P Jeffrey Conn, Craig W Lindsley

Bioorg Med Chem Lett. 2011 May 1;21(9):2711-4.

PMID: 21183344

1

Functional Interaction of Metabotropic Glutamate Receptor 5 and NMDA-receptor by a Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator

Holger Rosenbrock, Gert Kramer, Scott Hobson, Eliza Koros, Marc Grundl, Matthias Grauert, Klaus G Reymann, Ulrich H Schröder

Eur J Pharmacol. 2010 Aug 10;639(1-3):40-6.

PMID: 20371241

1

Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-Potentiator ADX-47273

Darren W Engers, Alice L Rodriguez, Richard Williams, Alexis S Hammond, Daryl Venable, Oluwatomi Oluwatola, Gary A Sulikowski, P Jeffrey Conn, Craig W Lindsley

ChemMedChem. 2009 Apr;4(4):505-11.

PMID: 19197923

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