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ADX71743

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For Research Use Only | Not For Clinical Use
CATAP1431641290
CAS1431641-29-0
MDL NumberMFCD30474715
Molecular Weight269.34
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and in Vivo Characterization

Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A Neale, Thomas E Salt, etc.

J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.

PMID: 23257312

1

Development of Allosteric Modulators of GPCRs for Treatment of CNS Disorders

Hilary Highfield Nickols, P Jeffrey Conn

Neurobiol Dis. 2014 Jan;61:55-71.

PMID: 24076101

1

Metabotropic Glutamate Receptor Subtype 7 in the Dorsal Striatum Oppositely Modulates Pain in Sham and Neuropathic Rats

Ida Marabese, Serena Boccella, Monica Iannotta, Livio Luongo, Vito de Novellis, Francesca Guida, Nicola Serra, Antonio Farina, Sabatino Maione, Enza Palazzo

Neuropharmacology. 2018 Jun;135:86-99.

PMID: 29505788

1

Negative Allosteric Modulation of the mGlu7 Receptor Reduces Visceral Hypersensitivity in a Stress-Sensitive Rat Strain

Rachel D Moloney, Anna V Golubeva, Richard M O'Connor, Mikhail Kalinichev, Timothy G Dinan, John F Cryan

Neurobiol Stress. 2015 Apr 4;2:28-33.

PMID: 26844237

1

Negative Allosteric Modulators of mGlu 7 Receptor as Putative Antipsychotic Drugs

Paulina Cieślik, Monika Woźniak, Katarzyna Kaczorowska, Piotr Brański, Grzegorz Burnat, Agnieszka Chocyk, Bartosz Bobula, Piotr Gruca, Ewa Litwa, Agnieszka Pałucha-Poniewiera, Agnieszka Wąsik, Andrzej Pilc, etc.

Front Mol Neurosci. 2018 Sep 20;11:316.

PMID: 30294258

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