CAS 497839-62-0 AEE788 - Analytical Products / Alfa Chemistry

CAT	AP497839620
CAS	497839-62-0
Molecular Weight	440.58
InChI Key	OONFNUWBHFSNBT-HXUWFJFHSA-N

Description	≥98% (HPLC)
Solubility	H2O: 10 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome

Catherine Sullenberger, Daniel Piqué, Yuko Ogata, Kojo Mensa-Wilmot

Mol Pharmacol. 2017 May;91(5):482-498.

PMID: 28246189

1

Concomitant Inhibition of Epidermal Growth Factor and Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Reduces Growth and Metastasis of Human Salivary Adenoid Cystic Carcinoma in an Orthotopic Nude Mouse Model

Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myers

Mol Cancer Ther. 2006 Nov;5(11):2696-705.

PMID: 17121916

1

Dual Inhibitor AEE788 Reduces Tumor Growth in Preclinical Models of Medulloblastoma

Daniela Meco, Tiziana Servidei, Gian Franco Zannoni, Enrica Martinelli, Maria Grazia Prisco, Chiara de Waure, Riccardo Riccardi

Transl Oncol. 2010 Oct 1;3(5):326-35.

PMID: 20885895

1

Multi-targeted Kinase Inhibition Alleviates mTOR Inhibitor Resistance in Triple-Negative Breast Cancer

Jichao He, Ronan P McLaughlin, Vera van der Noord, John A Foekens, John W M Martens, Gerard van Westen, Yinghui Zhang, Bob van de Water

Breast Cancer Res Treat. 2019 Nov;178(2):263-274.

PMID: 31388935

1

Pharmacokinetic Drug Interaction Between AEE788 and RAD001 Causing Thrombocytopenia in Patients With Glioblastoma

David A Reardon, Timothy Cloughesy, Jeremy Rich, W K Alfred Yung, Lotus Yung, Clifford DiLea, Jerry Huang, Margaret Dugan, William Mietlowski, Andrea Maes, Charles Conrad

Cancer Chemother Pharmacol. 2012 Jan;69(1):281-7.

PMID: 21984222

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