0

AGI-5198

INQUIRY Add to cart
For Research Use Only | Not For Clinical Use
CATAP1355326350
CAS1355326-35-0
Structure
Molecular Weight462.56
Description≥98% (HPLC)
SolubilityDMSO: 3 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Jennifer Tsoi, Owen Clark, Barbara Oldrini, Evangelia Komisopoulou, Kaiko Kunii, Alicia Pedraza, Stefanie Schalm, etc.

Science. 2013 May 3;340(6132):626-30.

PMID: 23558169

1

IDH1 R132H Causes Resistance to HDAC Inhibitors by Increasing NANOG in Glioblastoma Cells

Geon-Hee Kim, So Young Choi, Taek-In Oh, Sang-Yeon Kan, Hyeji Kang, Sujin Lee, Taerim Oh, Hyun Myung Ko, Ji-Hong Lim

Int J Mol Sci. 2019 May 31;20(11):2679.

PMID: 31151327

1

Isocitrate Dehydrogenase 1 Mutation Sensitizes Intrahepatic Cholangiocarcinoma to the BET Inhibitor JQ1

Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Yasuo Tanaka, Hideaki Ijichi, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Saburo Matsubara, Yousuke Nakai, etc.

Cancer Sci. 2018 Nov;109(11):3602-3610.

PMID: 30156013

1

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198

Remco J Molenaar, Dennis Botman, Myrthe A Smits, Vashendriya V Hira, Sanne A van Lith, Jan Stap, Peter Henneman, Mohammed Khurshed, Krissie Lenting, Adri N Mul, Dionysia Dimitrakopoulou, Cornelis M van Drunen, etc.

Cancer Res. 2015 Nov 15;75(22):4790-802.

PMID: 26363012

1

Synthesis and Evaluation of Radiolabeled AGI-5198 Analogues as Candidate Radiotracers for Imaging Mutant IDH1 Expression in Tumors

Satish K Chitneni, Zachary J Reitman, Rebecca Spicehandler, David M Gooden, Hai Yan, Michael R Zalutsky

Bioorg Med Chem Lett. 2018 Feb 15;28(4):694-699.

PMID: 29366652

  • Verification code
Contact Us

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.
Online Inquiry

Inquiry

For any inquiry, question or recommendation, please call: or fill out the following form.

  • Verification code

Head Office

  • Tel:
  • Email:

Follow us on

qrcode