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AK-7

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For Research Use Only | Not For Clinical Use
CATAP420831409
CAS420831-40-9
Structure
MDL NumberMFCD03140195
Molecular Weight437.35
InChI KeyIYAYHZZWYNXHEQ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: ≥15 mg/mL
Assay≥98% (HPLC)
Colorwhite to tan
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Aging-related Rotenone-Induced Neurochemical and Behavioral Deficits: Role of SIRT2 and Redox Imbalance, and Neuroprotection by AK-7

Xijin Wang, Qiang Guan, Meihua Wang, Liu Yang, Jie Bai, Zhiqiang Yan, Yuhong Zhang, Zhenguo Liu

Drug Des Devel Ther. 2015 May 7;9:2553-63.

PMID: 26089639

1

Corrigendum to "The SIRT2 Inhibitor AK-7 Decreases Cochlear Cell Apoptosis and Attenuates Noise-Induced Hearing Loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646]

Yongzhi Liu, Liying Ao, Yelin Li, Yuanyuan Zhao, Yuting Wen, Haitao Ding

Biochem Biophys Res Commun. 2019 Mar 26;511(1):201.

PMID: 30773260

1

Neuroprotective Effect of Sirt2-specific Inhibitor AK-7 Against Acute Cerebral Ischemia Is P38 Activation-dependent in Mice

Danhong Wu, Wenmei Lu, Zhenyu Wei, Ming Xu, Xueyuan Liu

Neuroscience. 2018 Mar 15;374:61-69.

PMID: 29382550

1

The SIRT2 Inhibitor AK-7 Decreases Cochlear Cell Apoptosis and Attenuates Noise-Induced Hearing Loss

Yongzhi Liu, Liying Ao, Yelin Li, Yuanyuan Zhao, Yuting Wen, Haitao Ding

Biochem Biophys Res Commun. 2019 Feb 12;509(3):641-646.

PMID: 30616888

1

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington's Disease Mouse Models

Vanita Chopra, Luisa Quinti, Jinho Kim, Lorraine Vollor, K Lakshmi Narayanan, Christina Edgerly, Patricia M Cipicchio, Molly A Lauver, Soo Hyuk Choi, Richard B Silverman, Robert J Ferrante, Steven Hersch, etc.

Cell Rep. 2012 Dec 27;2(6):1492-7.

PMID: 23200855

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