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Akt Inhibitor

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For Research Use Only | Not For Clinical Use
CATIAR42415210
Molecular Weight578.78
DescriptionThe Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SolubilityDMSO: 200 mg/mL
Assay≥98% (NMR)
Colorwhite to off-white
Formsolid; desiccated
Size1MG
Storage Conditions-20C
1

Akt in Cancer: Mediator and More

Sundaramoorthy Revathidevi, Arasambattu Kannan Munirajan

Semin Cancer Biol. 2019 Dec;59:80-91.

PMID: 31173856

1

PI3K/Akt Inhibitor Partly Decreases TNF-α-induced Activation of Fibroblast-Like Synoviocytes in Osteoarthritis

Songyang Liu, Chenxi Cao, Yujun Zhang, Guangyu Liu, Weixia Ren, Yanqi Ye, Tiezheng Sun

J Orthop Surg Res. 2019 Dec 11;14(1):425.

PMID: 31829201

1

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

Jörn Weisner, Ina Landel, Christoph Reintjes, Niklas Uhlenbrock, Marija Trajkovic-Arsic, Niklas Dienstbier, Julia Hardick, Swetlana Ladigan, Marius Lindemann, Steven Smith, Lena Quambusch, Rebekka Scheinpflug, etc.

Cancer Res. 2019 May 1;79(9):2367-2378.

PMID: 30858154

1

Targeting AKT1-E17K and the PI3K/AKT Pathway With an Allosteric AKT Inhibitor, ARQ 092

Yi Yu, Ronald E Savage, Sudharshan Eathiraj, Justin Meade, Michael J Wick, Terence Hall, Giovanni Abbadessa, Brian Schwartz

PLoS One. 2015 Oct 15;10(10):e0140479.

PMID: 26469692

1

Targeting the PI3K/Akt/mTOR Pathway With the pan-Akt Inhibitor GDC-0068 in PIK3CA-mutant Breast Cancer Brain Metastases

Franziska Maria Ippen, Julia Katharina Grosch, Megha Subramanian, Benjamin Macfarlane Kuter, Bianca M Liederer, Emile G Plise, Joana Liliana Mora, Naema Nayyar, Stephen Paul Schmidt, Anita Giobbie-Hurder, etc.

Neuro Oncol. 2019 Nov 4;21(11):1401-1411.

PMID: 31173106

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