Name: 11-Aminoundecyltriethoxysilane
SKU: APB116821455
Rating: 5 (1 reviews)

MDL Number	MFCD08272792
Molecular Weight	333.59
Molecular Formula	C17H39NO3Si

Boiling Point	128-132 °C
Flash Point	>37 °C
Purity	95%
Density	0.900 g/ml

Case Study

11-Aminoundecyltriethoxysilane for the Preparation of Stable Amino-Functionalized Self-Assembled Monolayers on Silica and Mica Substrates

Giraud, Lucie, et al. Applied Surface Science 370 (2016): 476-485.

11-Aminoundecyltriethoxysilane (AUTES) was employed for the fabrication of robust amino-functionalized self-assembled monolayers (SAMs) on mica and silica substrates, targeting applications in biosensors and nanomaterials. The long alkyl chain of AUTES, combined with its triethoxysilyl moiety, allowed covalent attachment to hydroxylated surfaces through straightforward solution-based self-assembly or controlled vapor-phase deposition. The resulting SAMs exhibited uniform surface coverage with high grafting density, enabling a controlled presentation of amino groups.
Hydrolytic stability of the AUTES SAMs was exceptional, retaining structural integrity over a broad pH range (2-10) for periods up to 8 days. This stability was attributed to the long-chain architecture and homogeneous monolayer formation, which protected Si-O-Si surface bonds from hydrolysis. The functional reactivity of the amino groups was confirmed through successful covalent immobilization of carboxyl-functionalized nanoparticles, demonstrating the compatibility of AUTES monolayers with subsequent surface chemistries.
AUTES SAMs prepared from solution involved immersion in absolute ethanol solutions (0.125-1 mM) for 20 minutes to 6 hours, followed by annealing at 120 °C for 45 minutes. Vapor-phase deposition similarly yielded homogeneous SAMs under mild vacuum conditions, avoiding condensation artifacts and ensuring consistent flux of silane vapor.
This study highlights AUTES as a superior aminoalkylsilane for generating durable and reactive SAMs on silica-based substrates, combining hydrolytic stability, high surface coverage, and functional versatility. These properties make AUTES an ideal candidate for advanced surface engineering in biosensor design, nanoparticle immobilization, and nanomaterial functionalization.

11-Aminoundecyltriethoxysilane for the Preparation of Functionalized Electrospun Polycaprolactone Scaffolds for Peripheral Nerve Regeneration

Taylor, Caroline S., et al. Macromolecular Bioscience 23.11 (2023): 2300226.

11-Aminoundecyltriethoxysilane (CL11) was employed to modify aligned electrospun polycaprolactone (PCL) scaffolds, creating amine-functionalized surfaces designed to enhance peripheral nerve regeneration. The modification was achieved through surface deposition of CL11 following oxygen plasma treatment, resulting in the covalent grafting of long-chain aminosilane onto the PCL fibers. This dual modification significantly altered surface chemistry and topography, decreasing water contact angle, increasing surface roughness, and introducing reactive -NH2 groups at the submicron scale.
Characterization via atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) confirmed uniform CL11 deposition and a significant increase in reactive surface sites. In vitro studies demonstrated that CL11-modified scaffolds supported NG108-15 neuronal cell viability and differentiation, while maintaining Schwann cell phenotype. Furthermore, 3D ex vivo culture of dorsal root ganglion (DRG) explants showed enhanced Schwann cell migration and longer neurite outgrowth on CL11-modified fibers compared to unmodified scaffolds.
The long-chain architecture of CL11 enabled precise control of surface chemistry and topography, which in turn directed cell adhesion, growth, and differentiation. Importantly, this scalable and cost-effective modification allows further functionalization of the scaffolds with bioactive molecules such as growth factors, therapeutic agents, or antimicrobial compounds through the amine groups.
This study highlights CL11 as a versatile silane reagent for the preparation of functionalized PCL scaffolds, providing a reproducible strategy to enhance peripheral nerve guidance devices. The approach demonstrates how surface chemistry modulation at the submicron scale can directly influence cell behavior, offering a promising route for advanced tissue engineering and regenerative medicine applications.

11-Aminoundecyltriethoxysilane for the Surface Functionalization of TiO2 Nanoparticles to Enhance Toughened Epoxy Nanocomposites

Zewde, B., P. Pitliya, and D. Raghavan. Journal of materials science 51.20 (2016): 9314-9329.

11-Aminoundecyltriethoxysilane (AUTES) was utilized to functionalize TiO2 nanoparticles with the aim of improving the mechanical and thermal performance of rubber-toughened epoxy nanocomposites. TiO2 nanoparticles were dispersed in anhydrous toluene and reacted with AUTES under ultrasonication and reflux conditions for 24 hours, enabling covalent grafting of long-chain aminosilane onto the nanoparticle surfaces. Excess silane was removed via sequential washing with toluene, methanol, and dichloromethane, and the functionalized TiO2 (TiO2-AUTES) was dried at 100 °C. FTIR, TGA, and contact angle measurements confirmed successful functionalization, with a graft density of 13.7% for AUTES-modified TiO2.
The functionalized nanoparticles were incorporated into carboxyl-terminated butadiene (CTBN) toughened epoxy resin via ultrasonication and high-shear mixing, followed by curing. The addition of TiO2-AUTES compensated for the loss in modulus typically observed with rubber tougheners while significantly enhancing fracture energy. Comparative studies demonstrated that TiO2-AUTES filled CTBN epoxy exhibited superior toughness without compromising tensile strength, outperforming both unmodified TiO2 filled and CTBN-only epoxy systems.
This study underscores the role of 11-aminoundecyltriethoxysilane as an effective surface modifier for inorganic nanoparticles, providing enhanced interfacial bonding with polymer matrices. The long-chain amine functionality not only ensures stable grafting but also contributes to improved load transfer, toughness, and thermal stability in epoxy nanocomposites. These findings highlight AUTES-functionalized TiO2 nanoparticles as promising fillers for advanced structural materials requiring high toughness and durability.