CAS 54301-15-4 Amsacrine hydrochloride - Analytical Products / Alfa Chemistry

CAT	AP54301154
CAS	54301-15-4
Structure
MDL Number	MFCD07799963
Molecular Weight	429.92
InChI Key	WDISRLXRMMTXEV-UHFFFAOYSA-N

Description	≥98% (TLC), powder
Solubility	DMSO: 10 mg/mL (with heat and sonication); 30% ethanol: 4 mg/mL
Assay	≥98% (TLC)
Color	red to brown
Form	powder
MP	197-199 °C (lit.)
Size	10MG, 50MG

1

A Carbamate Analogue of Amsacrine With Activity Against Non-Cycling Cells Stimulates Topoisomerase II Cleavage at DNA Sites Distinct From Those of Amsacrine

B C Baguley, F Leteurtre, J F Riou, G J Finlay, Y Pommier

Eur J Cancer. 1997 Feb;33(2):272-9.

PMID: 9135499

1

Amsacrine Suppresses Matrix metalloproteinase-2 (MMP-2)/MMP-9 Expression in Human Leukemia Cells

Wen-Hsin Liu, Ying-Jung Chen, Jen-Hung Chien, Long-Sen Chang

J Cell Physiol. 2014 May;229(5):588-98.

PMID: 24122234

1

Cellular Responses to methyl-N-[4-9-acridinylamino)-2-methoxyphenyl] Carbamate Hydrochloride, an Analogue of Amsacrine Active Against Non-Proliferating Cells

N Moreland, G J Finlay, M Dragunow, K M Holdaway, B C Baguley

Eur J Cancer. 1997 Sep;33(10):1668-76.

PMID: 9389932

1

Identification of Compounds That Modulate Retinol Signaling Using a Cell-Based qHTS Assay

Yanling Chen, Srilatha Sakamuru, Ruili Huang, David H Reese, Menghang Xia

Toxicol In Vitro. 2016 Apr;32:287-96.

PMID: 26820057

1

Nucleic Acid Binding drugs--XIV. The Crystal Structure of 1-methyl Amsacrine Hydrochloride; Relationships to DNA-binding Ability and Anti-Tumour Activity

S Neidle, G D Webster, B C Baguley, W A Denny

Biochem Pharmacol. 1986 Nov 15;35(22):3915-21.

PMID: 3778515

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