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Anle138b

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For Research Use Only | Not For Clinical Use
CATAP882697009
CAS882697-00-9
Molecular Weight343.17
InChI KeyRCQIIBJSUWYYFU-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Anle138b Modulates α-synuclein Oligomerization and Prevents Motor Decline and Neurodegeneration in a Mouse Model of Multiple System Atrophy

Antonio Heras-Garvin, Daniel Weckbecker, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Armin Giese, Gregor K Wenning, Nadia Stefanova

Mov Disord. 2019 Feb;34(2):255-263.

PMID: 30452793

1

Anle138b: A Novel Oligomer Modulator for Disease-Modifying Therapy of Neurodegenerative Diseases Such as Prion and Parkinson's Disease

Jens Wagner, Sergey Ryazanov, Andrei Leonov, Johannes Levin, Song Shi, Felix Schmidt, Catharina Prix, Francisco Pan-Montojo, Uwe Bertsch, Gerda Mitteregger-Kretzschmar, Markus Geissen, Martin Eiden, Fabienne Leidel, etc.

Acta Neuropathol. 2013 Jun;125(6):795-813.

PMID: 23604588

1

Depopulation of Dense α-synuclein Aggregates Is Associated With Rescue of Dopamine Neuron Dysfunction and Death in a New Parkinson's Disease Model

Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantini

Acta Neuropathol. 2019 Oct;138(4):575-595.

PMID: 31165254

1

Photophysics of Diphenyl-Pyrazole Compounds in Solutions and α-synuclein Aggregates

Anne M Reiner, Felix Schmidt, Sergey Ryazanov, Andrei Leonov, Daniel Weckbecker, Andreas A Deeg, Christian Griesinger, Armin Giese, Wolfgang Zinth

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):800-807.

PMID: 29273222

1

The Diphenylpyrazole Compound anle138b Blocks Aβ Channels and Rescues Disease Phenotypes in a Mouse Model for Amyloid Pathology

Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei-Ghaleh, Petra Wilken, etc.

EMBO Mol Med. 2018 Jan;10(1):32-47.

PMID: 29208638

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