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AS605240

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For Research Use Only | Not For Clinical Use
CATAP648450297-A
CAS648450-29-7
Structure
MDL NumberMFCD11100415
Molecular Weight257.27
InChI KeySQWZFLMPDUSYGV-POHAHGRESA-N
Description≥98% (HPLC)
SolubilityDMSO: 1 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Color, faint red to orange to dark brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Phosphoinositide 3-kinase-gamma Inhibitor, AS605240 Prevents Bleomycin-Induced Pulmonary Fibrosis in Rats

Xin Wei, Jing Han, Zhi-zhi Chen, Bao-wen Qi, Guang-cheng Wang, Ying-hua Ma, Hao Zheng, You-fu Luo, Yu-quan Wei, Li-juan Chen

Biochem Biophys Res Commun. 2010 Jun 25;397(2):311-7.

PMID: 20510675

1

Inhibition of phosphatidylinositol-3 Kinase γ Reduces Pruriceptive, Inflammatory, and Nociceptive Responses Induced by Trypsin in Mice

Paula Juliana Seadi Pereira, Lais Fernanda Lazarotto, Paulo César Leal, Tiago Giuliani Lopes, Fernanda Bueno Morrone, Maria Martha Campos

Pain. 2011 Dec;152(12):2861-9.

PMID: 22001656

1

Inhibition of PI3Kγ by AS605240 Protects tMCAO Mice by Attenuating Pro-Inflammatory Signaling and Cytokine Release in Reactive Astrocytes

Sen Shang, Lin Liu, Xingjuan Wu, Fan Fan, Erling Hu, Leilei Wang, Yan Ding, Yali Zhang, Xiaoyun Lu

Neuroscience. 2019 Sep 1;415:107-120.

PMID: 31195053

1

Inhibitor of PI3Kγ Ameliorates TNBS-induced Colitis in Mice by Affecting the Functional Activity of CD4+CD25+FoxP3+ Regulatory T Cells

R C Dutra, M Cola, D F P Leite, A F Bento, R F Claudino, A F Z Nascimento, P C Leal, J B Calixto

Br J Pharmacol. 2011 May;163(2):358-74.

PMID: 21244371

1

PI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke

Rong Jin, Adam Y Xiao, Jarvis Li, Min Wang, Guohong Li

Hypertension. 2019 Jan;73(1):206-216.

PMID: 30571560

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