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AT9283

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For Research Use Only | Not For Clinical Use
CATAP896466049
CAS896466-04-9
Structure
MDL NumberMFCD12031513
Molecular Weight381.43
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein

Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall

Mol Pharmacol. 2019 Nov;96(5):629-640.

PMID: 31515284

1

A Phase I and Pharmacodynamic Study of AT9283, a Small-Molecule Inhibitor of Aurora Kinases in Patients With relapsed/refractory Leukemia or Myelofibrosis

James Foran, Farhad Ravandi, William Wierda, Guillermo Garcia-Manero, Srdan Verstovsek, Tapan Kadia, Jan Burger, Murray Yule, Gillian Langford, John Lyons, John Ayrton, Victoria Lock, Gautham Borthakur, etc.

Clin Lymphoma Myeloma Leuk. 2014 Jun;14(3):223-30.

PMID: 24355079

1

AT9283, a Novel Aurora Kinase Inhibitor, Suppresses Tumor Growth in Aggressive B-cell Lymphomas

Wenqing Qi, Xiaobing Liu, Laurence S Cooke, Daniel O Persky, Thomas P Miller, Matthew Squires, Daruka Mahadevan

Int J Cancer. 2012 Jun 15;130(12):2997-3005.

PMID: 21796626

1

Optimizing and Predicting the in Vivo Activity of AT9283 as a Monotherapy and in Combination With Paclitaxel

Emad Y Moawad

J Gastrointest Cancer. 2015 Dec;46(4):380-9.

PMID: 26346504

1

Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer

Christopher C Mills, E A Kolb, Valerie B Sampson

Cancer Res. 2017 Dec 1;77(23):6489-6498.

PMID: 29097609

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