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Avagacestat

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For Research Use Only | Not For Clinical Use
CATAP1146699662
CAS1146699-66-2
Structure
MDL NumberMFCD13195458
Molecular Weight520.88
InChI KeyXEAOPVUAMONVLA-QGZVFWFLSA-N
Description≥98% (HPLC)
SolubilityDMSO: 30 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

A Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Avagacestat (BMS-708163) in Healthy Young and Elderly Subjects

Randy Dockens, Jun-Sheng Wang, Lorna Castaneda, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu, Oi Wong, Hewei Li, Robert M Berman, Christina Smith, Charles F Albright, Gary Tong

Clin Pharmacokinet. 2012 Oct 1;51(10):681-93.

PMID: 23018531

1

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human

T Karelina, O Demin, T Nicholas, Y Lu, S Duvvuri, H A Barton

CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):666-675.

PMID: 28571112

1

Effects of Single Doses of Avagacestat (BMS-708163) on Cerebrospinal Fluid Aβ Levels in Healthy Young Men

Gary Tong, Lorna Castaneda, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu, Oi Wong, Hewei Li, Robert M Berman, Christina Smith, Charles Albright, Randy C Dockens

Clin Drug Investig. 2012 Nov;32(11):761-9.

PMID: 23018285

1

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

Aitana Sogorb-Esteve, María-Salud García-Ayllón, Marta Llansola, Vicente Felipo, Kaj Blennow, Javier Sáez-Valero

Mol Neurobiol. 2018 Jun;55(6):5047-5058.

PMID: 28815510

1

Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial

Vladimir Coric, Stephen Salloway, Christopher H van Dyck, Bruno Dubois, Niels Andreasen, Mark Brody, Craig Curtis, Hilkka Soininen, Stephen Thein, Thomas Shiovitz, Gary Pilcher, Steven Ferris, Susan Colby, etc.

JAMA Neurol. 2015 Nov;72(11):1324-33.

PMID: 26414022

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