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AZ11645373

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For Research Use Only | Not For Clinical Use
CATAP227088940
CAS227088-94-0
Structure
Molecular Weight463.51
Description≥98% (HPLC), solid
SolubilityDMSO: ≥10 mg/mL
Assay≥98% (HPLC)
Colortan
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

Characterization of a Selective and Potent Antagonist of Human P2X(7) Receptors, AZ11645373

L Stokes, L-H Jiang, L Alcaraz, J Bent, K Bowers, M Fagura, M Furber, M Mortimore, M Lawson, J Theaker, C Laurent, M Braddock, A Surprenant

Br J Pharmacol. 2006 Dec;149(7):880-7.

PMID: 17031385

1

Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket

Anfal Bin Dayel, Richard J Evans, Ralf Schmid

Mol Pharmacol. 2019 Sep;96(3):355-363.

PMID: 31263019

1

Mechanism of Action of Species-Selective P2X(7) Receptor Antagonists

Anton D Michel, Sin-Wei Ng, Shilina Roman, William C Clay, David K Dean, Daryl S Walter

Br J Pharmacol. 2009 Apr;156(8):1312-25.

PMID: 19309360

1

Off-Target Anti-Inflammatory Activity of the P2X7 Receptor Antagonist AZ11645373

Olga V Oskolkova, Viktoria Godschachner, Valery N Bochkov

Inflammation. 2017 Apr;40(2):530-536.

PMID: 28101847

1

Repurposing Drugs Targeting the P2X7 Receptor to Limit Hyperinflammation and Disease During Influenza Virus Infection

Sarah Rosli, Francis J Kirby, Kate E Lawlor, Kate Rainczuk, Grant R Drummond, Ashley Mansell, Michelle D Tate

Br J Pharmacol. 2019 Oct;176(19):3834-3844.

PMID: 31271646

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