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AZ20

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For Research Use Only | Not For Clinical Use
CATAP1233339224
CAS1233339-22-4
Structure
MDL NumberMFCD25976730
Molecular Weight412.51
InChI KeySCGCBAAYLFTIJU-CQSZACIVSA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase With Application as an Anticancer Agent

Kevin M Foote, J Willem M Nissink, Thomas McGuire, Paul Turner, Sylvie Guichard, James W T Yates, Alan Lau, Kevin Blades, Dan Heathcote, Rajesh Odedra, Gary Wilkinson, Zena Wilson, Christine M Wood, Philip J Jewsbury

J Med Chem. 2018 Nov 21;61(22):9889-9907.

PMID: 30346772

1

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase With Monotherapy in Vivo Antitumor Activity

Kevin M Foote, Kevin Blades, Anna Cronin, Shaun Fillery, Sylvie S Guichard, Lorraine Hassall, Ian Hickson, Xavier Jacq, Philip J Jewsbury, Thomas M McGuire, J Willem M Nissink, Rajesh Odedra, Ken Page, etc.

J Med Chem. 2013 Mar 14;56(5):2125-38.

PMID: 23394205

1

Inhibition of ATR Potentiates the Cytotoxic Effect of Gemcitabine on Pancreatic Cancer Cells Through Enhancement of DNA Damage and Abrogation of Ribonucleotide Reductase Induction by Gemcitabine

Shuang Liu, Yubin Ge, Tingting Wang, Holly Edwards, Qihang Ren, Yiqun Jiang, Chengshi Quan, Guan Wang

Oncol Rep. 2017 Jun;37(6):3377-3386.

PMID: 28440428

1

Mechanisms Responsible for the Synergistic Antileukemic Interactions Between ATR Inhibition and Cytarabine in Acute Myeloid Leukemia Cells

Jun Ma, Xinyu Li, Yongwei Su, Jianyun Zhao, Daniel A Luedtke, Valeria Epshteyn, Holly Edwards, Guan Wang, Zhihong Wang, Roland Chu, Jeffrey W Taub, Hai Lin, Yue Wang, Yubin Ge

Sci Rep. 2017 Feb 8;7:41950.

PMID: 28176818

1

Susceptibility of Pseudaletia Unipuncta (Lepidoptera: Noctuidae) to Entomopathogenic Nematodes (Rhabditida: Steinernematidae and Heterorhabditidae) Isolated in the Azores: Effect of Nematode Strain and Host Age

J Medeiros, J S Rosa, J Tavares, N Simões

J Econ Entomol. 2000 Oct;93(5):1403-8.

PMID: 11057710

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