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AZD1152-HQPA

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For Research Use Only | Not For Clinical Use
CATAP722544516
CAS722544-51-6
Structure
MDL NumberMFCD10687152
Molecular Weight507.56
InChI KeyQYZOGCMHVIGURT-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: >15 mg/mL
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size10MG, 50MG
Storage Conditions2-8°C
1

AZD1152-HQPA Induces Growth Arrest and Apoptosis in Androgen-Dependent Prostate Cancer Cell Line (LNCaP) via Producing Aneugenic Micronuclei and Polyploidy

Ali Zekri, Seyed H Ghaffari, Samad Ghanizadeh-Vesali, Marjan Yaghmaie, Arash Salmaninejad, Kamran Alimoghaddam, Mohammad H Modarressi, Ardeshir Ghavamzadeh

Tumour Biol. 2015 Feb;36(2):623-32.

PMID: 25277659

1

Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA

Ali Zekri, Seyed H Ghaffari, Marjan Yaghmaie, Mehrdad Asghari Estiar, Kamran Alimoghaddam, Mohammad Hossein Modarressi, Ardeshir Ghavamzadeh

Mol Neurobiol. 2016 Apr;53(3):1808-1823.

PMID: 25752998

1

Preclinical Evaluation of the Aurora Kinase Inhibitors AMG 900, AZD1152-HQPA, and MK-5108 on SW-872 and 93T449 Human Liposarcoma Cells

Sandhya Noronha, Lauren A C Alt, Taylor E Scimeca, Omran Zarou, Justyna Obrzut, Brian Zanotti, Elizabeth A Hayward, Akhil Pillai, Shubha Mathur, Joseph Rojas, Ribhi Salamah, Nalini Chandar, Michael J Fay

In Vitro Cell Dev Biol Anim. 2018 Jan;54(1):71-84.

PMID: 29197031

1

Reactive Oxygen Species Generation and Increase in Mitochondrial Copy Number: New Insight Into the Potential Mechanism of Cytotoxicity Induced by Aurora Kinase Inhibitor, AZD1152-HQPA

Ali Zekri, Yashar Mesbahi, Samad Ghanizadeh-Vesali, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari

Anticancer Drugs. 2017 Sep;28(8):841-851.

PMID: 28639950

1

The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA)

Ali Zekri, Yashar Mesbahi, Elham Boustanipour, Zahra Sadr, Seyed H Ghaffari

J Mol Neurosci. 2018 Aug;65(4):444-455.

PMID: 30051358

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